Novelty P3 reductions in depression: Characterization using principal components analysis (PCA) of current source density (CSD) waveforms

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Novelty P3 reductions in depression: characterization using principal components analysis (PCA) of current source density (CSD) waveforms.

We previously reported a novelty P3 reduction in depressed patients compared to healthy controls (n=20 per group) in a novelty oddball task using a 31-channel montage. In an independent replication and extension using a 67-channel montage (n=49 per group), reference-free current source density (CSD) waveforms were simplified and quantified by a temporal, covariance-based principal components an...

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Current Source Density analysis (CSD) is a class of methods of analysis of extracellular electric potentials recorded at multiple sites leading to estimates of current sources generating the measured potentials. It is usually applied to low-frequency part of the potential (called the Local Field Potential, LFP) and to simultaneous recordings or to recordings taken with fixed time reference to t...

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OBJECTIVE Definition of appropriate frequency bands and choice of recording reference limit the interpretability of quantitative EEG, which may be further compromised by distorted topographies or inverted hemispheric asymmetries when employing conventional (non-linear) power spectra. In contrast, fPCA factors conform to the spectral structure of empirical data, and a surface Laplacian (2-dimens...

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Ion diffusion may introduce spurious current sources in current-source density (CSD) analysis

Current-source density (CSD) analysis is a well-established method for analyzing recorded local field potentials (LFPs), that is, the low-frequency part of extracellular potentials. Standard CSD theory is based on the assumption that all extracellular currents are purely ohmic, and thus neglects the possible impact from ionic diffusion on recorded potentials. However, it has previously been sho...

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ژورنال

عنوان ژورنال: Psychophysiology

سال: 2010

ISSN: 0048-5772,1469-8986

DOI: 10.1111/j.1469-8986.2009.00880.x